MCM Molecular and Cellular Modeling

Molecular and Cellular Modeling
HITS gGmbH (formerly EML Research gGmbH), Heidelberg

Curriculum Vitae

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Personal info

First Name : Paolo

Surname : Mereghetti

Date of Birth 31/10/1981

e-mails : Paolo.Mereghetti@h-its.org , paolo.mereghetti@gmail.com

Education

Current position

BIOMS post-doc fellowship
Molecular and Cellular Modeling (MCM) group
HITS gGmbH, Heidelberg

November 2005 to February 2009

Ph.D. in biochemistry and biotechnology (3 years)
Molecular modelling group
Thesis title: Protein structure and function relationships: application of computational approaches to biological and biomedical problems.
University of Milano-Bicocca (UNIMIB), Milan, Italy

July 2005

MSc in bioinformatics (2 years degree)
Thesis title : Methods of refinement and validation of protein models
Department of biotechnology and bioscience, University of Milano-Bicocca (UNIMIB), Milan, Italy
Degree result : 110/110 cum laude

November 2003

BSc in molecular biotechnology (3 years degree)
Thesis title : Prediction of proteins Gas4 and Gas5 of Saccharomyces cerevisiae using fold recognition methods
Department of biotechnology and bioscience, University of Milano-Bicocca (UNIMIB), Milan, Italy
Degree result : 110/110

Foreign Languages

Good written and spoken English

Good spoken French

Informatics skills

Deep knowledge of administration of Linux systems

Management of High Performance Clusters Linux-based

Thorough knowledge of C++, FORTRAN 77/90, Matlab, Perl, HTML, Bash

Publications

Mereghetti P, Riccardi L, Brandsdal O B, Piercarlo F, De Gioia L, Papaleo E
Near Native-State Conformational Landscape of Psychrophilic and Mesophilic Enzymes: Probing the Folding Funnel Model
J. Phys. Chem. B, accepted, 2010

Ami D, Natalello A, Mereghetti P, Neri T, Zanoni M, Monti M, Doglia S M, Redi C A
FT-IR spectroscopy supported by PCA-LDA analysis for the study of embryonic stem cell differentiationa
Spectroscopy, in press ,2010

Papaleo E, Mereghetti P, Fantucci P, Grandori R, and De Gioia L
Free energy landscape, principal component analysis, and structural clustering to identify representative conformations from Molecular Dynamics simulations: the myogl obin case
J. Molecular Graphics and Modelling, 27:889-899 ,2009

Ghezzi D, Viscomi C, Ferlini A, Gualandi F, Mereghetti P, De Grandis D, Zeviani M
Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence
Human Mol Genetics , 18:1058-1064, 2009

Massa V, Fernandez-Vizarra E, Alshahwan S, Bakhsh E, Goffrini P, Ferrero I, Mereghetti P, D'Adamo P, GaspariniP, Zeviani M
Severe infantile encephalomyopathy caused by a mutation in COX6B1, a nu- cleus encoded subunit of cytochrome c oxidase
Am J Hum Genet. , 82(6):1281-1289, 2008

Mineri R., Rimoldi M., Burlina A., Koskull S., Perletti C., Bryce H., Von Dobel U., Mereghetti P., Di Meo I., Invernizzi F, Zeviani M., Uziel G., Tiranti V.
Identification of new mutations in the ETHE1 gene in a cohort of 14 patients presenting with Ethylmalonic Encephalopathy
Journal of Medical Genetics, 45:473-478, 2008

Mereghetti P., Ganadu M.L., Papaleo E., Fantucci P. and De Gioia L. Validation of protein models by neural network approach.
BMC Bioinformatic, 9:66, 2008

Valente L, Tiranti V, Marsano RM, Malfatti E, Fernandez-Vizarra E, Donnini C, Mereghetti P, De Gioia L, Burlina A, Castellan C, Comi GP, Savasta S, Ferrero I, Zeviani M.
Infantile encephalopathy and defective mitochondrial DNA translation in pa- tients with mutations of mitochondrial elongation factors EFG1 and EFTu.
Am J Hum Genet., 80(1):44-58, 2007

Ami D., Neri T., Natalello A., Mereghetti P., Doglia S.M., Zanoni M., Zuc- cotti M., Garagna S. and Redi C.A.
Embryonic stem cell differentiation studied by FT-IR spectroscopy
BBA - Molecular Cell Research, 1783(1):98-106, 2007

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